Donnelly Mass Spectrometry Center (DMSC)

Hosted by the University of Toronto’s Donnelly Centre for Cellular and Biomolecular Research, the Donnelly Mass Spectrometry Center (DMSC) provides tailor-made services for characterization and quantification of proteins (proteomics) and small molecules (metabolomics). The DMSC operates on a cost-recovery model and operates the instruments at-cost for faculty members of the Donnelly Centre and academic collaborators from across Canada.

Currently, the facility supports multiple workflows. Whole-cell quantitative proteomics allows users to obtain quantitative information about thousands of proteins present in a sample from a single analysis. Accurate quantitation can be performed label-free, using isobaric labels (TMT), or using stable isotope labelling (SILAC etc). This workflow is amenable to cell cultures, bacterial cultures or tissues.

The DMSC houses two mass spectrometric instruments for proteomic analysis (Thermo Scientific LTQ Orbitrap Velos and Thermo Scientific QExactive HF) which allow high-throughput analysis of complex proteomes, metabolomes, PTMS, etc.


Terrence Donnelly Centre for Cellular & Biomolecular Research – Room 643
160 College Street
Toronto, Ontario
M5S 3E1

Areas of Expertise

Mass spectrometry


Product R&D
Materials R&D
Facility Access & Testing

Contact Information


Email: Edyta Marcon – Senior Research Associate –

Twitter: @DonnellyCentre

LinkedIn: Donnelly Centre for Cellular and Biomolecular Research

Published: January 24, 2022

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